The toolbar Launch Game button opens the Launch Game dialog. From here you pick a starting level, toggle launch options, then hit Start Alien: Isolation.
Options patch the game install and (for some UI mods) replace GFX files under DATA/UI.PAK. Some options aren't supported on all platforms — for example Cinematic Tools and Hot Reloading are Steam-only.
The Starting Level dropdown lists levels from the current game install. OpenCAGE prefers the level you're editing, otherwise your last used choice, otherwise the frontend.
Your selection is remembered for next time.
These swap in OpenCAGE's modified pause/frontend/loading/game-over menus (by patching GFX files inside UI.PAK — see also the UI Editor):
Mem_Replay_Logs folderOutside the Launch Game dialog: